Optical Coherence Tomography Angiographic Assessment of Polycythaemia Vera-Related Retinal Microvascular Morphological Changes: A Cross-Sectional Case-Control Study

Objective: To assess polycythaemia vera (PV)-related retinal microvascular morphological changes using optical coherence tomography angiography (OCTA). Material and Methods: In this cross-sectional case-control study, 30 PV patients (Group 1) healthy individuals 2) underwent a comprehensive ophthalmological examination, followed by OCTA acquisition in Angio Retina mode (6x6 mm). Macular superficial deep vascular plexus vessel densities (VDs) foveal, parafoveal, perifoveal, as well foveal avascular zone (FAZ) area, FAZ perimeter, VD 300-µm wide region around (FD-300) were automatically analysed AngioVue Analytics software. Sequential measurements compared for statistical significance. Results: Mean ages 46.97±3.20 47.42±2.55 years Groups 1 2, respectively (p=0.350). Group had significantly increased than 2 (p=0.032). Besides, non-significantly VDs the following areas: whole (p=0.468), parafoveal (p=0.692), (p=0.752), perifoveal (p=0.369), perimeter (p=0.209), FD-300 (p=0.914). The area decreased to (p=0.529). Conclusion: appears be associated with considerable changes, indicating potential hyperviscosity impact on that would necessitate careful consideration during patient evaluation.